Human Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) Protein
312€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694153
tested applications
SDS-PAGE
Description
Human Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 28.16 kDa Observed MW (SDS-PAGE): 45 kDa Sequence Fragment: Met1-Asn257 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | P20333 |
| Gene ID | 7133 |
| OMIM | 191191 |
| Alias | Tumor necrosis factor receptor superfamily member 1B,p75,TBPII,TNFBR,TNFR2,CD120b,TNFR1B,TNFR80,TNF-R75,p75TNFR,TNF-R-II,Tumor necrosis factor receptor 2,p80 TNF-alpha receptor |
| Background | Protein TNFRSF1B |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TNFRSF1B, also known as Tumor Necrosis Factor Receptor Superfamily Member 1B or TNFR2, is a cell surface receptor predominantly expressed on immune cells, including regulatory T cells (Tregs), endothelial cells, and neurons. TNFR2 is one of the two primary receptors for tumor necrosis factor-alpha (TNF-α), along with TNFR1 (TNFRSF1A). Although TNFR1 and TNFR2 both bind TNF-α, they have unique and overlapping roles within immune responses. TNFR2 primarily activates pathways that promote cell survival, tissue regeneration, and anti-inflammatory responses, differentiating it from TNFR1, which is more commonly associated with apoptosis and pro-inflammatory signaling. The TNFRSF1B gene is located on chromosome 1p36.22 and encodes a receptor of 461 amino acids. TNFR2 is a key component in regulating inflammation, modulating T cell activity, and contributing to vascular health. Its interaction with TNF-α can activate both canonical (NF-κB) and non-canonical pathways, resulting in varying cellular responses depending on the cellular environment and receptor activation context.
Related Products
Human TNFRSF1B (Tumor necrosis factor receptor superfamily member 1B) ELISA Kit
Ver Producto
TNFRSF1B antibody
Ver Producto