Human Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Human Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168222
tested applications
WB, SDS-PAGE
Description
Tumor Necrosis Factor Receptor Superfamily, Member 1A Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 21.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr60-Tyr236 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P19438 |
| Gene ID | 7132 |
| OMIM | 142680 |
| Alias | FPF,p55,p60,TBP1,TNF-R,TNFAR,TNFR1,p55-R,CD120a,TNFR55,TNFR60,TNF-R-I,TNF-R55,Tumor necrosis factor receptor superfamily member 1A,Tumor necrosis factor receptor type I |
| Background | Protein TNFRSF1A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TNFRSF1A , also known as Tumor Necrosis Factor Receptor Superfamily Member 1A or TNFR1 , is a prominent cell surface receptor that binds tumor necrosis factor-alpha (TNF-α). TNFR1 plays a critical role in regulating immune responses, cell survival, apoptosis, and inflammation, making it an essential component in both innate and adaptive immunity. The TNFRSF1A gene is located on chromosome 12p13.31 and encodes a protein that is expressed in nearly all cell types, with high expression in immune cells, epithelial cells, and neurons. As a member of the TNF receptor superfamily, TNFRSF1A is involved in multiple signaling pathways, depending on cellular and environmental conditions. Upon binding to TNF-α, TNFR1 can trigger both pro-inflammatory responses and cell death pathways, depending on the context of signaling and additional molecules present. This receptor’s dual role is tightly regulated, as overactivation of TNFR1-mediated pathways can lead to pathological inflammation, while insufficient TNFR1 activity may hinder immune responses.
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