Human Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A) Protein

Este producto es parte de TNFRSF1A - TNF receptor superfamily member 1A
Human Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein TNFRSF1A

proveedor

Abbexa

reference

abx166964

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Tumor Necrosis Factor Receptor Superfamily, Member 1A Protein is a recombinant Human protein expressed in E. coli.


Background

TNFRSF1A , also known as Tumor Necrosis Factor Receptor Superfamily Member 1A or TNFR1 , is a prominent cell surface receptor that binds tumor necrosis factor-alpha (TNF-α). TNFR1 plays a critical role in regulating immune responses, cell survival, apoptosis, and inflammation, making it an essential component in both innate and adaptive immunity. The TNFRSF1A gene is located on chromosome 12p13.31 and encodes a protein that is expressed in nearly all cell types, with high expression in immune cells, epithelial cells, and neurons. As a member of the TNF receptor superfamily, TNFRSF1A is involved in multiple signaling pathways, depending on cellular and environmental conditions. Upon binding to TNF-α, TNFR1 can trigger both pro-inflammatory responses and cell death pathways, depending on the context of signaling and additional molecules present. This receptor’s dual role is tightly regulated, as overactivation of TNFR1-mediated pathways can lead to pathological inflammation, while insufficient TNFR1 activity may hinder immune responses.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 23.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys248-Met428 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TNFRSF1A


dry ice

No


availability

Shipped within 5-7 working days.


alias

FPF,p55,p60,TBP1,TNF-R,TNFAR,TNFR1,p55-R,CD120a,TNFR55,TNFR60,TNF-R-I,TNF-R55,Tumor necrosis factor receptor superfamily member 1A,Tumor necrosis factor receptor type I


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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