Human Tumor Necrosis Factor Receptor Superfamily Member 10A / CD261 (TNFRSF10A) Protein (Active)
780€ (100 µg)
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Name
Human Tumor Necrosis Factor Receptor Superfamily Member 10A / CD261 (TNFRSF10A) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691770
Tested Applications
SDS-PAGE
Description
Human TRAIL R1 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human TNFRSF10A (NP_003835.2) extracellular domain (Met 1-Asn 239) was expressed, fused with a polyhistidine tag at the C-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | TRAIL R1 |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Asn239 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 15.7 kDa |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_003835.2 |
| Alias | DR4,APO2,CD261,TRAILR1,TRAILR-1,Death receptor 4,NF-related apoptosis-inducing ligand receptor 1 |
| Background | Protein TNFRSF10A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg as determined by the LAL method. |
Background
TNFRSF10A (TNF receptor superfamily member 10a), also known as TRAIL receptor 1 (TRAIL-R1) or death receptor 4 (DR4), is a member of the TNF receptor superfamily. TNFRSF10A is primarily recognized for its ability to bind to TRAIL (TNF-related apoptosis-inducing ligand), a pro-apoptotic ligand that induces cell death selectively in transformed or cancerous cells. TRAIL and its receptors are part of a critical signaling axis that regulates apoptosis, especially in response to cellular stress and immune-mediated cell targeting. The receptor is expressed on the cell surface of a variety of tissues and has been implicated in numerous physiological processes, including tumor surveillance, immune response, and inflammatory regulation. Due to its ability to mediate apoptosis in abnormal cells while sparing normal cells, TNFRSF10A has gained attention in cancer research as a therapeutic target
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