Human Transmembrane Emp24 Domain Containing Protein 4 (TMED4) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Transmembrane Emp24 Domain Containing Protein 4 (TMED4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx383787
tested applications
ELISA
Description
Human Transmembrane Emp24 Domain Containing Protein 4 (TMED4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human TMED4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transmembrane Emp24 Domain Containing Protein 4 (TMED4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q7Z7H5 |
| Gene ID | 222068 |
| OMIM | 612038 |
| Alias | ERS25, GMP25iso, HNLF, p24a3, p24alpha3,Putative NF-kappa-B-activating protein 156,p24 family protein alpha-3,p24alpha3 |
| Background | Elisa kits for TMED4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TMED4, a key p24 family member, participates in the regulation of vesicle-mediated trafficking in the early secretory pathway, facilitating cargo transport between the ER, ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. TMED4 interacts with coat proteins (COPII and COPI) to enable vesicle budding, cargo sorting, and retrieval, ensuring protein quality control and proper trafficking dynamics. It also contributes to maintaining Golgi organization, regulating secretory pathway efficiency, and supporting protein maturation processes. TMED4 is widely expressed across various tissues, particularly in actively secreting cells, where it supports cellular homeostasis and organelle function. Dysregulation of TMED4 is associated with neurodegeneration, metabolic disorders, and cancers, where altered trafficking pathways lead to protein mislocalization and cellular stress. Knockdown studies reveal disrupted vesicle formation, increased ER stress, and impaired protein transport, underscoring its role in coordinating intracellular trafficking, protein stability, and cellular function.
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