Human Transforming Growth Factor Beta 2 (TGFb2) Protein

Este producto es parte de TGFB- Transforming Growth Factor Beta
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728€ (50 µg)

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935106861
info@markelab.com
name
Human Transforming Growth Factor Beta 2 (TGFb2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx655842
tested applications
WB, SDS-PAGE

Description

Human Transforming Growth Factor Beta 2 (TGFb2) Protein (Active) is an Active Recombinant Human protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Transforming Growth Factor Beta 2 (TGFb2)
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 16.6 kDa  Observed MW (SDS-PAGE): 17 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser303-Glu414
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
G-TSF,LDS4,TGF-beta2,Cetermin,Glioblastoma-derived T-cell suppressor factor
Background
Protein TGFB2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

TGFB2 is a member of the TGF-β cytokine family, which regulates a wide range of cellular processes, including proliferation, differentiation, migration, apoptosis, and immune suppression. TGFB2 is critically involved in embryogenesis, particularly in the development of the heart, lungs, and central nervous system, as well as in tissue homeostasis and repair. It signals through SMAD-dependent and non-SMAD pathways, modulating gene expression and cellular responses to environmental stimuli. TGFB2 plays an essential role in immune regulation, where it suppresses inflammation and promotes tolerance by inducing regulatory T cell (Treg) development. Dysregulation of TGFB2 is implicated in developmental disorders, fibrosis, and tumor progression, where it drives epithelial-mesenchymal transition (EMT) and facilitates immune evasion. Knockout studies show severe developmental defects, including cardiac abnormalities, craniofacial malformations, and impaired organogenesis, underscoring TGFB2’s importance in tissue development, immune modulation, and homeostatic maintenance.

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