Human Transcription factor E2F6 (E2F6) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for E2F6
proveedor
Abbexareference
abx520215Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Transcription factor E2F6 (E2F6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Transcription factor E2F6 (E2F6) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
E2F6 is a unique member of the E2F family that functions primarily as a transcriptional repressor independent of retinoblastoma (RB) proteins. Unlike other E2F family members, E2F6 lacks a transactivation domain and instead represses gene expression through association with polycomb group (PcG) proteins and chromatin-modifying complexes. E2F6 plays a critical role in gene silencing during the G1/S transition and is particularly involved in maintaining transcriptional repression during cell differentiation and development. It regulates genes involved in DNA repair, meiosis, and embryonic patterning by modulating chromatin structure. E2F6 is highly expressed in embryonic stem cells and germ cells, where it prevents aberrant transcription of proliferation-associated genes. Knockout studies reveal defects in meiosis and homeotic gene expression, highlighting its importance in chromatin remodeling, developmental regulation, and transcriptional repression.
Características del producto
category
ELISA Kits
immunogen target
Transcription factor E2F6 (E2F6)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
E2F-6
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
E2F6
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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