Human Transcription factor E2F6 (E2F6) ELISA Kit
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Description
Human Transcription factor E2F6 (E2F6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Transcription factor E2F6 (E2F6) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transcription factor E2F6 (E2F6) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O75461 |
| Gene ID | 1876 |
| OMIM | 602944 |
| Alias | E2F-6 |
| Background | Elisa kits for E2F6 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
E2F6 is a unique member of the E2F family that functions primarily as a transcriptional repressor independent of retinoblastoma (RB) proteins. Unlike other E2F family members, E2F6 lacks a transactivation domain and instead represses gene expression through association with polycomb group (PcG) proteins and chromatin-modifying complexes. E2F6 plays a critical role in gene silencing during the G1/S transition and is particularly involved in maintaining transcriptional repression during cell differentiation and development. It regulates genes involved in DNA repair, meiosis, and embryonic patterning by modulating chromatin structure. E2F6 is highly expressed in embryonic stem cells and germ cells, where it prevents aberrant transcription of proliferation-associated genes. Knockout studies reveal defects in meiosis and homeotic gene expression, highlighting its importance in chromatin remodeling, developmental regulation, and transcriptional repression.
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