Human TNF Receptor Associated Factor 1 (TRAF1) Protein
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935106861
info@markelab.com
Precio
156€ (10 µg)
Protein TRAF1
proveedor
Abbexareference
abx650678Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human TRAF1 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
TRAF1 is an adaptor protein in the tumor necrosis factor receptor (TNFR) superfamily signaling pathways, playing a role in regulating NF-κB and MAPK activation, apoptosis, and immune responses. TRAF1 interacts with TNFR1, TNFR2, and other members of the TNF receptor family to mediate downstream signaling, promoting survival and inflammatory responses. TRAF1 is predominantly expressed in immune cells, including T cells, B cells, and macrophages, where it modulates cytokine production and apoptosis inhibition. It forms heterodimers with TRAF2 to regulate receptor complex formation and downstream signal transduction. Dysregulation of TRAF1 contributes to autoimmune diseases, chronic inflammation, and certain cancers by altering TNF signaling and immune responses. Knockdown studies show defects in cytokine production, reduced NF-κB activation, and increased susceptibility to apoptosis, underscoring its role in balancing immune homeostasis and cell survival pathways.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
TNF Receptor Associated Factor 1 (TRAF1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 58.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly131-Ala381 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TRAF1
dry ice
No
availability
Shipped within 5-7 working days.
alias
TRAF-1,TRAF1,EBI6, MGC:10353, TNF receptor associated factor 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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