Human Thyroid Stimulating Hormone Receptor (TSHR) Protein

Este producto es parte de TSHR - Thyroid Stimulating Hormone Receptor
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208€ (10 µg)

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935106861
info@markelab.com
name
Human Thyroid Stimulating Hormone Receptor (TSHR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652205
tested applications
WB, SDS-PAGE

Description

Thyroid Stimulating Hormone Receptor (TSHR) Protein is a Recombinant protein from Human.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Thyroid Stimulating Hormone Receptor (TSHR)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 48.3 kDa  Observed MW (SDS-PAGE): 50 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Gly21-Gly413
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
TSHR,Thyrotropin Receptor,LGR3,TSH-R,CHNG1,hTSHR-I
Background
Protein TSHR
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

TSHR is a G protein-coupled receptor activated by thyroid-stimulating hormone (TSH), a pituitary hormone that regulates thyroid gland growth and function. TSHR is primarily expressed on thyroid follicular cells, where its activation stimulates the production and release of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). TSHR signaling occurs via Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and stimulation of thyroid hormone synthesis, iodide uptake, and cell proliferation. TSHR plays a critical role in maintaining metabolic homeostasis, thermoregulation, and growth. Dysregulation of TSHR signaling is associated with thyroid disorders, such as Graves' disease (autoimmune hyperthyroidism), where TSHR autoantibodies lead to excessive hormone production, and hypothyroidism caused by receptor mutations. TSHR is also a target in thyroid cancers, where its overactivation promotes tumor growth. TSHR agonists and antagonists are being explored for therapeutic applications in thyroid dysfunction and thyroid-related cancers. TSHR is central to thyroid hormone regulation and overall metabolic balance.

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