Human Thyroid-Stimulating Hormone Receptor (TSHR) Protein

Product specifications

Proteins and Peptides

Thyroid-Stimulating Hormone Receptor (TSHR)

E. coli

Optimal dilutions/concentrations should be determined by the end user.

Human

Unconjugated

Molecular Weight: 26 kDa

Concentration: 1 mg/ml

Sequence Fragment: 22-260 AA.

Tag: His tag

Recombinant

> 95% (SDS-PAGE)

100 µg

1 mg

Liquid

ELISA, SDS-PAGE

10 mM PBS, pH 7.4, containing 10% glycerol and 0.01% Proclin-300.

Shipped within 5-10 working days.

Aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze/thaw cycles.

No

P16473

7253

603372

TSHR,Thyrotropin Receptor,LGR3,TSH-R,CHNG1,hTSHR-I

Protein TSHR

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

TSHR is a G protein-coupled receptor activated by thyroid-stimulating hormone (TSH), a pituitary hormone that regulates thyroid gland growth and function. TSHR is primarily expressed on thyroid follicular cells, where its activation stimulates the production and release of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). TSHR signaling occurs via Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and stimulation of thyroid hormone synthesis, iodide uptake, and cell proliferation. TSHR plays a critical role in maintaining metabolic homeostasis, thermoregulation, and growth. Dysregulation of TSHR signaling is associated with thyroid disorders, such as Graves' disease (autoimmune hyperthyroidism), where TSHR autoantibodies lead to excessive hormone production, and hypothyroidism caused by receptor mutations. TSHR is also a target in thyroid cancers, where its overactivation promotes tumor growth. TSHR agonists and antagonists are being explored for therapeutic applications in thyroid dysfunction and thyroid-related cancers. TSHR is central to thyroid hormone regulation and overall metabolic balance.

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The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.

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