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Human Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
587.5€ (96 tests)
Elisa Kits TERF2IP
proveedor
Abbexareference
abx573994Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Telomeric Repeat Binding Factor 2 Interacting Protein concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TERF2IP, also known as RAP1, is a key component of the shelterin complex that interacts with TERF2 to regulate telomere protection and maintenance. While TERF2IP does not directly bind to telomeric DNA, it associates with TERF2 to stabilize telomeric t-loops, preventing chromosome end fusions and inappropriate activation of DNA damage signaling pathways. TERF2IP is also involved in non-telomeric functions, including transcriptional regulation, NF-κB signaling, and metabolic control, highlighting its broader cellular roles. It is widely expressed in proliferative tissues, where it maintains telomere length homeostasis and protects chromosome ends during replication. Dysregulation of TERF2IP has been linked to premature aging, genomic instability, and cancer, where altered shelterin function results in telomere dysfunction and increased susceptibility to DNA damage. Functional studies show that TERF2IP loss leads to telomere deprotection, chromosomal instability, and activation of p53-mediated cell cycle arrest, underscoring its essential role in telomere maintenance, genomic stability, and transcriptional regulation.
Características del producto
category
ELISA Kits
immunogen target
Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)
reactivity
Human
test range
1.56 ng/ml - 100 ng/ml
sensitivity
0.94 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
RAP1,TERF2-interacting telomeric protein 1,TRF2-interacting telomeric protein 1,DRIP5
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
TERF2IP
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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