Human Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
611€ (96 tests)
Elisa kits for TERF2IP
proveedor
Abbexareference
abx573994Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Telomeric Repeat Binding Factor 2 Interacting Protein concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TERF2IP, also known as RAP1, is a key component of the shelterin complex that interacts with TERF2 to regulate telomere protection and maintenance. While TERF2IP does not directly bind to telomeric DNA, it associates with TERF2 to stabilize telomeric t-loops, preventing chromosome end fusions and inappropriate activation of DNA damage signaling pathways. TERF2IP is also involved in non-telomeric functions, including transcriptional regulation, NF-κB signaling, and metabolic control, highlighting its broader cellular roles. It is widely expressed in proliferative tissues, where it maintains telomere length homeostasis and protects chromosome ends during replication. Dysregulation of TERF2IP has been linked to premature aging, genomic instability, and cancer, where altered shelterin function results in telomere dysfunction and increased susceptibility to DNA damage. Functional studies show that TERF2IP loss leads to telomere deprotection, chromosomal instability, and activation of p53-mediated cell cycle arrest, underscoring its essential role in telomere maintenance, genomic stability, and transcriptional regulation.
Características del producto
category
ELISA Kits
immunogen target
Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)
reactivity
Human
test range
1.56 ng/ml - 100 ng/ml
sensitivity
0.94 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
RAP1,TERF2-interacting telomeric protein 1,TRF2-interacting telomeric protein 1,DRIP5
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TERF2IP
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
anti- TERF2IP antibody
proveedor
FineTestreference
FNab08599Tested Applications
ELISA, WB, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalThe gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on ...
Precio a consultar
Ver másTelomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) Antibody
proveedor
Abbexareference
abx007105Tested Applications
IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalTERF2IP Antibody is a Rabbit Polyclonal Antibody against TERF2IP.
312€ (60 µl)
Ver másTelomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) Antibody
proveedor
Abbexareference
abx027763Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalThe gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on ...
292.5€ (80 µl)
Ver más