Human Tachykinin Receptor 1 (TACR1) CLIA Kit
643.5€ (96 tests)
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name
Human Tachykinin Receptor 1 (TACR1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196084
tested applications
CLIA
Description
Human Tachykinin Receptor 1 (TACR1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Tachykinin Receptor 1 (TACR1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Tachykinin Receptor 1 (TACR1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 62.5 pg/ml - 4000 pg/ml |
| Sensitivity | 37.5 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | TACR1,SPR,Substance P receptor,NK1R,TAC1R,neurokinin receptor 1,NK1 receptor,NKIR |
| Background | CLIA Kits TACR1 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TACR1 is a G protein-coupled receptor (GPCR) that is activated by neurokinin A (NKA) and substance P, which are neuropeptides from the tachykinin family. TACR1 primarily couples to Gq proteins, which activate phospholipase C (PLC), leading to the production of inositol triphosphate (IP3) and the release of intracellular calcium. This results in smooth muscle contraction, vasodilation, and increased cell signaling. TACR1 is expressed in various tissues, including the central nervous system (CNS), gastrointestinal tract, and vasculature. In the CNS, TACR1 regulates pain perception, mood, and anxiety, while in the gastrointestinal system, it is involved in regulating motility and inflammation. Dysregulation of TACR1 signaling has been implicated in pain disorders, such as chronic inflammatory pain, and conditions like asthma and irritable bowel syndrome (IBS). Targeting TACR1 with antagonists is being explored as a potential therapy for pain management and other inflammatory diseases.
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