Human T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein CD3E
proveedor
Abbexareference
abx069250Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
CD3E (CD3 epsilon) is one of the key subunits of the T-cell receptor (TCR)-CD3 complex, which is vital for T-cell activation and immune responses. The TCR complex allows T lymphocytes to recognize and respond to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). CD3E plays a critical role in assembling the TCR-CD3 complex and facilitating signal transduction after antigen recognition. The CD3E gene is located on chromosome 11q23 and encodes the CD3ε chain, a type I transmembrane protein essential for the assembly, expression, and signaling function of the TCR. Along with other CD3 subunits (CD3δ, CD3γ, and CD3ζ), CD3E forms part of the signal-transducing complex that transmits signals from the TCR upon antigen engagement. This signal initiates the cascade that leads to T-cell activation, differentiation, and proliferation, all of which are crucial for immune defense against pathogens.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 21.4 kDa Observed MW (SDS-PAGE): 22 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met28-Asn185 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
CD3E
dry ice
No
availability
Shipped within 5-7 working days.
alias
T3E,TCRE,IMD18,CD3epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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