Human Suppressor Of Cytokine Signaling 6 (SOCS6) ELISA Kit
715€ (96 tests)
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Name
Human Suppressor Of Cytokine Signaling 6 (SOCS6) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx383371
Tested Applications
ELISA
Description
Human Suppressor Of Cytokine Signaling 6 (SOCS6) ELISA Kit is an ELISA kit against Human Suppressor Of Cytokine Signaling 6 (SOCS6).
Documentos del producto
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Suppressor Of Cytokine Signaling 6 (SOCS6) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O14544 |
| Gene ID | 9306 |
| OMIM | 605118 |
| Alias | SOSC6,CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4 |
| Background | Elisa Kits for: SOCS6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
SOCS6 is a member of the SOCS protein family that regulates cytokine and growth factor signaling pathways, particularly those mediated by insulin and receptor tyrosine kinases (RTKs). It inhibits signaling by targeting receptor complexes and signaling intermediates for ubiquitin-mediated degradation via its SOCS box domain, thus fine-tuning pathways such as the PI3K/Akt and MAPK cascades. SOCS6 is broadly expressed in tissues like the liver, pancreas, and skeletal muscle, where it regulates processes like cell growth, glucose metabolism, and insulin sensitivity. It has a role in tumor suppression by inhibiting growth factor signaling and promoting apoptosis in cancer cells. Dysregulation of SOCS6 is linked to metabolic disorders, including insulin resistance and diabetes, as well as cancer progression due to impaired signaling control. Knockdown studies reveal enhanced RTK activity, increased cellular proliferation, and reduced apoptosis, highlighting its role as a regulator of metabolic signaling, growth, and tumor suppression.
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