Human Suppressor Of Cytokine Signaling 5 (SOCS5) ELISA Kit
715€ (96 tests)
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name
Human Suppressor Of Cytokine Signaling 5 (SOCS5) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx383370
tested applications
ELISA
Description
Human Suppressor Of Cytokine Signaling 5 (SOCS5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SOCS5 concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Suppressor Of Cytokine Signaling 5 (SOCS5) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O75159 |
| Gene ID | 9655 |
| OMIM | 607094 |
| Alias | SOCS5,CIS6, CISH6, Cish5, SOCS-5,Cytokine-inducible SH2 protein 6,CIS-6,Cytokine-inducible SH2-containing protein 5,Cytokine-inducible SH2-containing protein 5 |
| Background | Elisa kits for SOCS5 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SOCS5 acts as a negative regulator of cytokine signaling by inhibiting JAK/STAT pathways and targeting signaling components for proteasomal degradation through its SOCS box domain. It interacts with cytokine receptors like IL-4Rα to regulate T-helper cell differentiation, particularly inhibiting Th2 responses and promoting immune balance. SOCS5 is expressed in lymphoid tissues, epithelial cells, and adipose tissues, where it modulates immune regulation, cytokine sensitivity, and energy homeostasis. It is particularly important for regulating allergic inflammation and T-cell polarization during immune responses. Dysregulation of SOCS5 is associated with allergic diseases, asthma, and autoimmune disorders due to imbalanced cytokine signaling. Functional studies reveal its role in controlling IL-4-driven responses, preventing excessive Th2-mediated inflammation. Knockout models demonstrate enhanced Th2 differentiation, increased allergic inflammation, and disrupted immune balance, emphasizing its role in maintaining cytokine homeostasis and adaptive immunity.
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