Human Sphingosine 1 Phosphate Receptor 3 (S1PR3) CLIA Kit

Este producto es parte de S1PR - Sphingosine 1 Phosphate Receptor
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845€ (96 tests)

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935106861
info@markelab.com
name
Human Sphingosine 1 Phosphate Receptor 3 (S1PR3) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx494698
tested applications
CLIA

Description

Human Sphingosine 1 Phosphate Receptor 3 (S1PR3) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
CLIA Kits
Immunogen Target
Sphingosine 1 Phosphate Receptor 3 (S1PR3)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
1.56 ng/ml - 100 ng/ml
Sensitivity
< 0.63 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
CLIA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-20 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
S1PR3,C9orf108,C9orf47,EDG-3,EDG3,LPB3,S1P3,endothelial differentiation G protein-coupled receptor 3
Background
CLIA Kits S1PR3
Status
RUO
Note
The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

S1PR3 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), widely expressed in endothelial cells, smooth muscle cells, and immune cells. It couples to multiple G proteins (Gq, Gi, and G12/13), activating signaling pathways such as PI3K/Akt, MAPK, and Rho/ROCK. S1PR3 regulates vascular tone, endothelial barrier integrity, and smooth muscle contraction, contributing to blood flow regulation and vascular development. It also influences immune cell migration, inflammatory responses, and cardiac function. In the cardiovascular system, S1PR3 is essential for vasodilation and cardioprotection. Dysregulation of S1PR3 has been associated with chronic inflammation, cardiovascular diseases, and cancer progression. In tumor biology, S1PR3 promotes angiogenesis, metastasis, and immune cell infiltration into the tumor microenvironment. Therapeutically, targeting S1PR3 is being explored for its potential to regulate vascular inflammation, immune responses, and cancer metastasis, making it a promising target in inflammatory and cardiovascular diseases.

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