Human SOCS4 (Suppressor Of Cytokine Signaling 4) ELISA Kit
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Name
Human SOCS4 (Suppressor Of Cytokine Signaling 4) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH4024
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 3.906-250pg/ml |
| Sensitivity | 2.344pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q8WXH5 |
| Alias | SOCS-4,Suppressor of cytokine signaling 7,SOCS-7 |
| Background | Elisa kits for SOCS4 |
| Status | RUO |
Background
SOCS4 is a member of the SOCS protein family that regulates cytokine signaling by inhibiting the Janus kinase (JAK)/STAT pathway and promoting the proteasomal degradation of signaling intermediates via its SOCS box domain. It interacts with phosphorylated cytokine receptors and downstream proteins to suppress excessive cytokine responses, particularly in pathways related to epidermal growth factor receptor (EGFR) and interleukin-4 (IL-4). SOCS4 is broadly expressed in tissues such as the liver, immune cells, and epithelial tissues, where it regulates processes like cell proliferation, differentiation, and immune homeostasis. It has been implicated in regulating inflammation and epithelial repair during infections. Dysregulation of SOCS4 is linked to chronic inflammation, impaired wound healing, and cancer progression, where excessive EGFR signaling promotes uncontrolled cell proliferation. Knockdown studies reveal hyperactivated cytokine signaling, increased inflammatory responses, and abnormal cellular growth, highlighting its critical role in balancing cytokine-mediated signaling pathways.
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