Human Sirtuin 1 (SIRT1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
578.5€ (96 tests)
Elisa kits for SIRT1
proveedor
Abbexareference
abx253177Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Sirtuin 1 (SIRT1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sirtuin 1 concentrations in tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Background
SIRT1 is a NAD+-dependent deacetylase and member of the sirtuin family that regulates cellular processes including gene expression, metabolism, DNA repair, and aging by removing acetyl groups from target proteins SIRT1 is highly expressed in various tissues, including the liver, brain, and skeletal muscle, where it modulates the activity of transcription factors such as p53, FOXO, NF-κB, and PPARγ coactivator-1α (PGC-1α) SIRT1 promotes cellular survival during stress by enhancing DNA repair, suppressing apoptosis, and regulating energy metabolism through mitochondrial biogenesis and fatty acid oxidation Activation of SIRT1 is associated with increased longevity and protection against age-related diseases such as type 2 diabetes, cardiovascular disease, neurodegeneration, and cancer Compounds like resveratrol act as SIRT1 activators to improve metabolic health by enhancing insulin sensitivity and mitochondrial function SIRT1 also inhibits inflammation by deacetylating NF-κB and reducing pro-inflammatory cytokine production, making it a key target for therapies in metabolic, inflammatory, and age-associated disorders
Características del producto
category
ELISA Kits
immunogen target
Sirtuin 1 (SIRT1)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
0.19 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
SIR2,SIR2L1,SIR2alpha,SIR2-like protein 1,Hsir2,NAD-dependent protein deacylase sirtuin-1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SIRT1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
Sirtuin 1 (SIRT1) Antibody
proveedor
Abbexareference
abx000615Tested Applications
WB, IF/ICCreactivity
Human, Mousestatus
RUOclonality
PolyclonalSIRT1 Antibody is a Rabbit Polyclonal antibody against SIRT1. This gene encodes a member of the sirtuin family of protei...
312€ (60 µl)
Ver másHuman Sirtuin 1 (SIRT1) CLIA Kit
proveedor
Abbexareference
abx196269Tested Applications
CLIAreactivity
Humanstatus
RUOHuman Sirtuin 1 (SIRT1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Sir...
643.5€ (96 tests)
Ver másSirtuin 1 (SIRT1) Antibody
proveedor
Abbexareference
abx430875Tested Applications
P-ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalSirtuin 1 Antibody is a Goat Polyclonal antibody against Sirtuin 1.
416€ (200 µl)
Ver más