Human Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7) Protein
221€ (10 µg)
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Name
Human Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx069071
Tested Applications
WB, SDS-PAGE
Description
Human Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gly18-Pro191 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 35.9 kDa Observed MW (SDS-PAGE): 44 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y286 |
| Alias | p75,QA79,AIRM1,CD328,AIRM-1,CDw328,D-siglec,SIGLEC-7,SIGLECP2,SIGLEC19P,p75/AIRM1,Adhesion inhibitory receptor molecule 1 |
| Background | Protein SIGLEC7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Endotoxin Level: <1.0 EU per 1µg (determined by the LAL method) Concentration: Prior to lyophilization: 200 µg/ml |
Background
SIGLEC7, also known as p75/AIRM1, is an inhibitory receptor expressed on natural killer (NK) cells and some myeloid cells. It binds preferentially to α2-8-linked disialic acids found on both self and microbial surfaces, helping to suppress inappropriate immune activation. SIGLEC7 transmits inhibitory signals via immunoreceptor tyrosine-based inhibitory motifs (ITIMs), reducing NK cell-mediated cytotoxicity. This protein plays a critical role in maintaining self-tolerance and modulating responses to cancer and viral infections. It is frequently studied for its involvement in tumor immune evasion and as a target for immunotherapy.
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