Human Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Protein
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935106861
info@markelab.com
Precio
2475€ (1 mg)
Protein SIGLEC5
proveedor
Abbexareference
abx069069Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) is a recombinant Human protein produced in E. coli using Prokaryotic expression.
Background
SIGLEC5 is an inhibitory receptor expressed on monocytes, neutrophils, and B cells. It binds to sialic acid-containing glycans on host and microbial surfaces, modulating immune responses to avoid excessive inflammation. Through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), SIGLEC5 dampens activation signals and helps maintain immune tolerance. This protein also plays a role in preventing inappropriate immune responses during pregnancy and infection. Genetic fusion events between SIGLEC5 and SIGLEC14 have been noted, affecting the functional balance between activation and inhibition. SIGLEC5 is studied for its involvement in autoimmune diseases and infections.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SIGLEC5
dry ice
No
availability
Shipped within 1-2 months.
alias
CD170,OBBP2,CD33L2,OB-BP2,SIGLEC-5,Obesity-binding protein 2,CD33 antigen-like 2
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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