Human SH3 Domain-Containing Kinase-Binding Protein 1 (SH3KBP1) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits SH3KBP1
proveedor
Abbexareference
abx259483Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human SH3 Domain-Containing Kinase-Binding Protein 1 (SH3KBP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SH3 Domain-Containing Kinase-Binding Protein 1 (SH3KBP1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SH3 Domain Containing Kinase Binding Protein 1 (SH3KBP1), also known as CIN85 (Cbl-interacting protein of 85 kDa), is a multi-domain adaptor protein involved in numerous cellular signaling pathways. It contains SH3 domains that facilitate interactions with various binding partners, making it a critical regulator of receptor endocytosis, cytoskeletal reorganization, and intracellular trafficking. SH3KBP1 plays a key role in downregulating activated receptor tyrosine kinases, such as EGFR, by recruiting ubiquitin ligases like Cbl, leading to receptor internalization and degradation. Additionally, it is implicated in actin cytoskeleton dynamics, thereby influencing processes such as cell migration and adhesion. SH3KBP1 also participates in immune signaling and synaptic transmission by modulating vesicular transport. Dysregulation of SH3KBP1 has been associated with cancer, particularly in pathways involving aberrant receptor signaling, as well as other diseases linked to defective endocytic or cytoskeletal mechanisms.
Características del producto
category
ELISA Kits
immunogen target
SH3 Domain-Containing Kinase-Binding Protein 1 (SH3KBP1)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.188 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
SH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2,Ruk
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SH3KBP1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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