Human Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Protein

Este producto es parte de ACVR - Activin A Receptor Type
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208€ (10 µg)

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935106861
info@markelab.com
name
Human Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652178
tested applications
WB, SDS-PAGE

Description

Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Protein is a Recombinant protein from Human.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Serine/threonine-Protein Kinase Receptor R3 (ACVRL1)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 29.2 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser238-Arg479
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 97%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P37023
Alias
Activin receptor-like kinase 1,ALK-1,SKR3
Background
Protein ACVRL1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.

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