Human Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) CLIA Kit

Human Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) CLIA Kit is a Sandwich CLIA Kit for use with Tissue homogenates, cell lysates and other biological fluids.

Background

ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.