Human SATB Homeobox Protein 2 (SATB2) Protein
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Description
Human SATB Homeobox Protein 2 (SATB2) Protein is a Recombinant Human protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | SATB Homeobox Protein 2 (SATB2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 40.6 kDa Observed MW (SDS-PAGE): 44 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys350-His672 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UPW6 |
| Alias | C2DELq32q33,DEL2Q32Q33,GLSS,Special AT-rich sequence-binding protein 2,DNA-binding protein SATB2 |
| Background | Protein SATB2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SATB homeobox 2 (SATB2) is a transcription factor that plays a crucial role in chromatin organization, gene regulation, and cellular differentiation SATB2 is involved in the regulation of skeletal development, neural differentiation, and craniofacial patterning, particularly during embryogenesis It functions by binding to specific DNA sequences and organizing chromatin into loops, facilitating the regulation of gene expression in a spatially organized manner SATB2 is highly expressed in osteoblasts and neurons, where it influences the expression of genes involved in bone formation and synaptic plasticity Mutations in SATB2 lead to developmental disorders such as SATB2-associated syndrome, which is characterized by intellectual disability, speech delays, and craniofacial abnormalities SATB2 also plays a role in cancer, where it can modulate tumor progression and metastasis through its effects on chromatin structure and gene expression Recent studies have highlighted its potential as a therapeutic target for regenerative medicine and in disorders involving disrupted bone and neural development
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anti- SATB2 antibody
Binds to DNA, at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons(UL1) specific genetic program and for the inactivation of deep-layer neurons(DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
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anti- SATB2 antibody
Binds to DNA, at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons(UL1) specific genetic program and for the inactivation of deep-layer neurons(DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
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