Human SAM and SH3 Domain-Containing Protein 1 (SASH1) ELISA Kit

Este producto es parte de SASH - SAM and SH3 domain containing
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715€ (96 tests)

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935106861
info@markelab.com
name
Human SAM and SH3 Domain-Containing Protein 1 (SASH1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385383
tested applications
ELISA

Description

Human SAM and SH3 Domain-Containing Protein 1 (SASH1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SAM and SH3 domain-containing protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
SAM and SH3 Domain-Containing Protein 1 (SASH1)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.12 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-20 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
O94885
Gene ID
23328
OMIM
127500
Alias
CAPOK,DUH,DUH1,SH3D6A,dJ323M4.1,Proline-glutamate repeat-containing protein
Background
Elisa kits for SASH1
Status
RUO
Note
Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

SAM and SH3 domain containing 1 (SASH1) is a scaffolding protein that functions as a tumor suppressor and a signaling adaptor in cellular processes such as adhesion, migration, and proliferation SASH1 contains SAM (Sterile Alpha Motif) and SH3 (Src Homology 3) domains that enable interactions with signaling molecules, linking it to pathways regulating cytoskeletal organization, inflammation, and apoptosis It is predominantly expressed in epithelial tissues and immune cells, where it modulates cell-cell adhesion and response to extracellular signals Loss or downregulation of SASH1 expression is associated with tumor progression, invasion, and poor prognosis in cancers such as breast, colorectal, and lung cancers, underscoring its role in suppressing metastasis SASH1 is also involved in regulating inflammatory pathways and immune responses, suggesting its broader role in maintaining tissue homeostasis Emerging studies highlight its importance in vascular remodeling and wound healing, where it influences endothelial cell function Its ability to interact with multiple signaling pathways makes SASH1 a key regulator of cell behavior and a potential therapeutic target in cancer and inflammatory diseases

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