Human Retinal-Specific ATP-Binding Cassette Transporter (ABCA4) Protein
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935106861
info@markelab.com
Precio
3770€ (5 mg)
Protein ABCA4
proveedor
Abbexareference
abx620135Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Retinal-Specific ATP-Binding Cassette Transporter (ABCA4) Protein is a recombinant protein produced in E. coli.
Background
ABCA4, also known as the photoreceptor-specific ABC transporter, is expressed in retinal photoreceptor cells, where it facilitates the transport of all-trans-retinal derivatives across photoreceptor disc membranes. This activity is vital for the visual cycle, as it prevents the accumulation of toxic retinoid byproducts that can damage photoreceptors. ABCA4 mutations are linked to several retinal degenerative diseases, including Stargardt disease, cone-rod dystrophy, and retinitis pigmentosa. Structurally, ABCA4 contains two transmembrane and two nucleotide-binding domains, characteristic of ABC transporters, which utilize ATP hydrolysis for substrate translocation. The proper function of ABCA4 is critical for maintaining retinal health and visual function, making it a target for therapeutic interventions in retinal disorders.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Retinal-Specific ATP-Binding Cassette Transporter (ABCA4)
host
E. coli
form
Lyophilized
tested applications
SDS-PAGE
size 1
5 mg
size 2
10 mg
observerd MW
Molecular Weight: Calculated MW: 13.71 kDa Sequence Fragment: 2174-2273aa Tag: N-terminal His tag
expression
Recombinant
purity
> 80% (SDS-PAGE)
recommended dilution
Optimal dilutions/concentrations should be determined by the end user.
buffer
Prior to lyophilization: PBS, pH 7.5.
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ABCA4
dry ice
No
availability
Shipped within 25-30 working days.
alias
ABC10,ABCR,ARMD2,CORD3,FFM,STGD1,ATP binding cassette subfamily A member 4
uniprot id
note
This product is for research use only. This product is shipped with ice packs. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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