The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.
Primary Antibodies
polyclonal
human
ABCA4
Rabbit
IgG
Unconjugated
liquid
ELISA, IHC
256 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
IHC: 1:20-1:200
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
ABCA4
ABC10,ABCR,ARMD2,CORD3,FFM,STGD1,ATP binding cassette subfamily A member 4
This product is for research use only.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transp...
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Ver másThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transp...
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Ver másABCA4 Antibody is a Rabbit Polyclonal against ABCA4.
175€ (20 µl)
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