Human Retinal-Specific ATP-Binding Cassette Transporter (ABCA4) Protein

Este producto es parte de ABCA4 - Retinal-Specific ATP-Binding Cassette Transporter
Human Retinal-Specific ATP-Binding Cassette Transporter (ABCA4) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein ABCA4

proveedor

Abbexa

reference

abx650373

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ABCA4 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ABCA4, also known as the photoreceptor-specific ABC transporter, is expressed in retinal photoreceptor cells, where it facilitates the transport of all-trans-retinal derivatives across photoreceptor disc membranes. This activity is vital for the visual cycle, as it prevents the accumulation of toxic retinoid byproducts that can damage photoreceptors. ABCA4 mutations are linked to several retinal degenerative diseases, including Stargardt disease, cone-rod dystrophy, and retinitis pigmentosa. Structurally, ABCA4 contains two transmembrane and two nucleotide-binding domains, characteristic of ABC transporters, which utilize ATP hydrolysis for substrate translocation. The proper function of ABCA4 is critical for maintaining retinal health and visual function, making it a target for therapeutic interventions in retinal disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Retinal-Specific ATP-Binding Cassette Transporter (ABCA4)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 40.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly1398-Asn1727 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCA4


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABC10,ABCR,ARMD2,CORD3,FFM,STGD1,ATP binding cassette subfamily A member 4


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reference

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reactivity

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status

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clonality

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