Human Retinal Dehydrogenase 1 (ALDH1A1) Protein
208€ (10 µg)
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Name
Human Retinal Dehydrogenase 1 (ALDH1A1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx650622
Tested Applications
WB, SDS-PAGE
Description
Human Retinal Dehydrogenase 1 (ALDH1A1) Protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Retinal Dehydrogenase 1 (ALDH1A1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser2-Ser501 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 58.4 kDa Observed MW (SDS-PAGE): 58 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00352 |
| Gene ID | 216 |
| OMIM | 100640 |
| Alias | 3-deoxyglucosone dehydrogenase 1,ALDH-E1,ALHDII |
| Background | Protein ALDH1A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-0.5 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 80 µg/ml |
Background
ALDH1A1 is a cytosolic enzyme primarily responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a biologically active metabolite of vitamin A that regulates gene expression via retinoic acid receptors (RARs). ALDH1A1 plays a pivotal role in embryonic development, cell differentiation, and tissue regeneration, particularly in the eyes, liver, and hematopoietic systems. It is a well-known marker for cancer stem cells (CSCs) in various tumors, including breast, lung, and prostate cancers, where its overexpression contributes to chemoresistance, metastasis, and tumor initiation. ALDH1A1 is also involved in detoxifying reactive aldehydes, such as 4-hydroxynonenal (4-HNE), providing protection against oxidative stress. Its role in maintaining stem cell populations and redox homeostasis highlights ALDH1A1 as a therapeutic target in oncology. Additionally, ALDH1A1 is implicated in alcohol metabolism and the development of alcohol-related liver diseases.
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