Human Retinal Dehydrogenase 1 (ALDH1A1) Protein
234€ (5 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Retinal Dehydrogenase 1 (ALDH1A1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073085
Tested Applications
SDS-PAGE
Description
Retinal Dehydrogenase 1 (ALDH1A1) is a recombinant enzyme.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Retinal Dehydrogenase 1 (ALDH1A1) |
| Host | E. coli |
| Assay Type | Activity: Not tested |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 2 weeks. Store at -20 °C for long term storage. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00352 |
| Gene ID | 216 |
| OMIM | 100640 |
| Alias | 3-deoxyglucosone dehydrogenase 1,ALDH-E1,ALHDII |
| Background | Protein ALDH1A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH1A1 is a cytosolic enzyme primarily responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a biologically active metabolite of vitamin A that regulates gene expression via retinoic acid receptors (RARs). ALDH1A1 plays a pivotal role in embryonic development, cell differentiation, and tissue regeneration, particularly in the eyes, liver, and hematopoietic systems. It is a well-known marker for cancer stem cells (CSCs) in various tumors, including breast, lung, and prostate cancers, where its overexpression contributes to chemoresistance, metastasis, and tumor initiation. ALDH1A1 is also involved in detoxifying reactive aldehydes, such as 4-hydroxynonenal (4-HNE), providing protection against oxidative stress. Its role in maintaining stem cell populations and redox homeostasis highlights ALDH1A1 as a therapeutic target in oncology. Additionally, ALDH1A1 is implicated in alcohol metabolism and the development of alcohol-related liver diseases.
Productos relacionados
Retinal Dehydrogenase 1 (ALDH1A1) Antibody
ALDH1A1 Antibody is a Rabbit Polyclonal antibody against ALDH1A1. The protein encoded by this gene belongs to the aldehy…
Ver producto
Retinal Dehydrogenase 1 (ALDH1A1) Antibody
ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde,…
Ver producto
Retinal Dehydrogenase 1 (ALDH1A1) Antibody
ALDH1A1 encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a…
Ver producto