Human Retinal Dehydrogenase 1 (ALDH1A1) ELISA Kit

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
Human Retinal Dehydrogenase 1 (ALDH1A1) ELISA Kit
715€ (96 tests)

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Name
Human Retinal Dehydrogenase 1 (ALDH1A1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx150607
Tested Applications
ELISA

Description

Human Retinal Dehydrogenase 1 (ALDH1A1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Retinal Dehydrogenase 1 (ALDH1A1) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Retinal Dehydrogenase 1 (ALDH1A1)

Documentos del producto

Instrucciones
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Data sheet
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Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Retinal Dehydrogenase 1 (ALDH1A1)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
1.56 ng/ml - 100 ng/ml
Sensitivity
< 0.63 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P00352
Gene ID
216
OMIM
100640
Alias
3-deoxyglucosone dehydrogenase 1,ALDH-E1,ALHDII
Background
Elisa Kits for: ALDH1A1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

ALDH1A1 is a cytosolic enzyme primarily responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a biologically active metabolite of vitamin A that regulates gene expression via retinoic acid receptors (RARs). ALDH1A1 plays a pivotal role in embryonic development, cell differentiation, and tissue regeneration, particularly in the eyes, liver, and hematopoietic systems. It is a well-known marker for cancer stem cells (CSCs) in various tumors, including breast, lung, and prostate cancers, where its overexpression contributes to chemoresistance, metastasis, and tumor initiation. ALDH1A1 is also involved in detoxifying reactive aldehydes, such as 4-hydroxynonenal (4-HNE), providing protection against oxidative stress. Its role in maintaining stem cell populations and redox homeostasis highlights ALDH1A1 as a therapeutic target in oncology. Additionally, ALDH1A1 is implicated in alcohol metabolism and the development of alcohol-related liver diseases.

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