Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) Protein

Este producto es parte de RXFP - Relaxin Insulin Like Family Peptide Receptor
Product Graph
1872€ (1 mg)

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935106861
info@markelab.com
name
Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654937
tested applications
WB, SDS-PAGE

Description

Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) Protein is a Recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
1 mg
Size 2
5 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 1-2 months.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
RXFP3, RLN3R1,RXFPR3,GPCR135,relaxin/insulin like family peptide receptor 3,SALPR
Background
Protein RXFP3
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

RXFP3 is a G protein-coupled receptor that is activated by relaxin-3, a member of the relaxin/insulin-like family. This receptor primarily couples to Gi proteins, leading to the inhibition of adenylate cyclase and reducing cAMP levels. RXFP3 is expressed in the central nervous system, particularly in regions such as the hypothalamus, where it plays a key role in regulating stress responses, appetite, and circadian rhythms. Activation of RXFP3 has been shown to influence feeding behavior, emotional responses, and neuroendocrine functions by modulating neurotransmitter release and neuronal excitability. Dysregulation of RXFP3 signaling is associated with disorders like anxiety, depression, and metabolic syndrome. As a therapeutic target, RXFP3 agonists could potentially be used to address stress-related conditions and appetite regulation, while antagonists may be useful in managing mood disorders and obesity.

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