Human Receptor Tyrosine-Protein Kinase ErbB-2 (ErbB2) Protein
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935106861
info@markelab.com
Precio
234€ (5 µg)
Protein ERBB2
proveedor
Abbexareference
abx073667Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Tyrosine Kinase ErbB-2 Protein is a recombinant protein kinases.
Background
ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Receptor Tyrosine-Protein Kinase ErbB-2 (ErbB2)
host
E. coli
form
Liquid
tested applications
SDS-PAGE
size 1
5 µg
size 2
20 µg
size 3
1 mg
expression
Recombinant
purity
> 95% (SDS-PAGE)
recommended dilution
Optimal dilutions/concentrations should be determined by the end user.
storage
Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
or code
ERBB2
dry ice
No
availability
Shipped within 5-10 working days.
alias
Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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