Human RAC-Gamma Serine/Threonine Protein Kinase (AKT3) ELISA Kit

Documentos del producto

Especificaciones del producto

ELISA Kits

RAC-Gamma Serine/Threonine Protein Kinase (AKT3)

Human

Colorimetric

Quantitative

Sandwich

1.56 ng/ml - 100 ng/ml

0.94 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Standard Form: Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-7 working days.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q9Y243

AKT3,PKBG,RAC-PK-gamma,STK-2

Elisa Kits for: AKT3

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

AKT3, also known as RAC-gamma serine/threonine-protein kinase, is one of the three isoforms of the AKT (Protein Kinase B) family of serine/threonine kinases. Like AKT1 and AKT2, AKT3 plays a crucial role in regulating various cellular processes, including cell survival, proliferation, growth, and metabolism. AKT3 is activated downstream of the phosphoinositide 3-kinase (PI3K) signaling pathway, which is activated by growth factors and other extracellular stimuli. Activation of AKT3 occurs through phosphorylation at key residues, including threonine 305 (Thr305) and serine 472 (Ser472). Once activated, AKT3 phosphorylates a wide range of substrates involved in diverse cellular functions. While AKT1 and AKT2 are ubiquitously expressed in many tissues, AKT3 exhibits a more restricted pattern of expression, with higher expression levels observed in the brain, heart, and skeletal muscle. This tissue-specific expression pattern suggests distinct roles for AKT3 in these tissues. AKT3 is involved in brain development and neuronal survival. Studies have shown that AKT3 plays a critical role in regulating neuronal migration, axon outgrowth, and dendritic arborization during brain development. Dysregulation of AKT3 signaling has been implicated in various neurological disorders, including autism spectrum disorders and epilepsy. AKT3 is also involved in other cellular processes such as cell proliferation, survival, and metabolism. Dysregulation of AKT3 signaling has been implicated in various diseases, including cancer, metabolic disorders, and cardiovascular diseases.

Productos relacionados

RAC-Gamma Serine/threonine-Protein Kinase (Akt3) Antibody

Akt3 (also designated protein kinase B gamma or v-akt murine thymoma viral oncogene homolog 3), with 479-amino acid prot…

Ver producto

RAC-Gamma Serine/threonine-Protein Kinase (AKT3) Antibody

AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regula…

Ver producto

AKT3 (pS472) Antibody

AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regula…

Ver producto