Human RAB5A, Member RAS Oncogene Family (RAB5A) Protein
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Description
RAB5A, Member RAS Oncogene Family Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | RAB5A, Member RAS Oncogene Family (RAB5A) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 27.2 kDa Observed MW (SDS-PAGE): 31 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ser214 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | RAB5,Ras-related protein Rab-5A |
| Background | Protein RAB5A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
RAB5A, member RAS oncogene family (RAB5A) is another member of the RAB family of small GTPases, playing a crucial role in regulating early endosome dynamics and vesicular trafficking RAB5A is involved in the initiation of endocytosis, controlling the fusion of early endosomes and the processing of internalized material It is essential for receptor-mediated endocytosis, where it helps sort and direct cargo for degradation or recycling within the cell RAB5A also participates in the regulation of cell signaling, including receptor tyrosine kinase signaling, and is involved in maintaining cellular communication and response to external signals Dysregulation of RAB5A activity has been linked to a variety of disorders, including cancer, where aberrant endosomal trafficking can influence tumor progression and metastasis Additionally, RAB5A plays a role in immune responses and the trafficking of immune receptors, further highlighting its importance in both normal cellular processes and disease pathogenesis
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