Human Proteinase-Activated Receptor 4 (F2RL3) CLIA Kit
845€ (96 tests)
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935106861
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name
Human Proteinase-Activated Receptor 4 (F2RL3) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx491085
tested applications
CLIA
Description
Human Protease Activated Receptor 4 (PAR4) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Proteinase-Activated Receptor 4 (F2RL3) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.122 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | F2RL3,coagulation factor II receptor-like 3,protease-activated receptor 4,thrombin receptor-like 3,thrombin receptor-like 3,F2R like thrombin/trypsin receptor 3,PAR4 |
| Background | CLIA Kits F2RL3 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Proteinase-Activated Receptor 4 (F2RL3), or PAR4, is activated by thrombin and other serine proteases, including trypsin. It is primarily expressed in platelets, endothelial cells, and various immune cells. F2RL3 plays a crucial role in platelet aggregation, clot formation, and wound healing. Upon activation, PAR4 signals through Gi proteins to modulate cellular responses such as platelet activation, granule release, and thrombus formation. PAR4 is a key mediator of thrombin-induced platelet responses and works in concert with other PARs (like PAR1 and PAR3) to regulate the coagulation cascade. Dysregulation of F2RL3 signaling has been associated with thrombotic disorders, such as deep vein thrombosis and stroke. PAR4 antagonists are being investigated for their potential to prevent thrombosis, especially in cardiovascular diseases where clot formation is a major contributor to disease progression. Additionally, F2RL3’s role in immune cell activation and inflammation suggests it could be a target for managing inflammatory diseases and autoimmune disorders, as well as regulating immune responses during infection.
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