Human Proteinase-Activated Receptor 1 (F2R) ELISA Kit

Este producto es parte de F2R - Proteinase-Activated Receptor
Human Proteinase-Activated Receptor 1 (F2R) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

546€ (96 tests)

Elisa kits for F2R

proveedor

Abbexa

reference

abx571468

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Proteinase-Activated Receptor 1 (F2R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Protease Activated Receptor 1 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

Proteinase-Activated Receptor 1 (F2R), or PAR1, is a G protein-coupled receptor activated by thrombin, a serine protease involved in coagulation and cellular signaling. PAR1 activation occurs through proteolytic cleavage of its N-terminal domain, exposing a tethered ligand that activates the receptor. PAR1 couples to Gq, Gi, and G12/13 proteins, triggering diverse signaling pathways, including phospholipase C (PLC), MAPK, and Rho-mediated pathways. PAR1 is widely expressed in endothelial cells, platelets, smooth muscle cells, and neurons, where it regulates thrombosis, inflammation, vascular permeability, and tissue repair. In platelets, PAR1 activation promotes aggregation and thrombus formation, while in endothelial cells, it modulates vascular integrity and inflammation. Dysregulation of PAR1 contributes to thrombotic disorders, cancer progression, and inflammatory diseases. PAR1 antagonists, such as vorapaxar, are clinically used to reduce thrombotic events in patients with cardiovascular disease. Targeting PAR1 offers therapeutic benefits in thrombosis, cancer, and inflammatory vascular disorders.

Características del producto

category

ELISA Kits


immunogen target

Proteinase-Activated Receptor 1 (F2R)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

0.1 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

F2R,protease-activated receptor 1,coagulation factor II, thrombin receptor,CF2R,HTR,PAR-1,PAR1,TR


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

F2R


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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