Human Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Protein
208€ (10 µg)
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935106861
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name
Human Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650362
tested applications
WB, SDS-PAGE
Description
Human PTPRU Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type U (PTPRU) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 25.0 kDa Observed MW (SDS-PAGE): 25 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg1263-Arg1446 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92729 |
| Alias | FMI,PTP,PCP-2,PTP-J,PTPRO,PTPU2,PTP-PI,PTP-RO,PTPPSI,hPTP-J,R-PTP-U,R-PTP-PSI,Protein-tyrosine phosphatase receptor omicron,Receptor-type protein-tyrosine phosphatase psi,Protein-tyrosine phosphatase J,Protein-tyrosine phosphatase pi,Pancreatic carcinoma phosphatase 2,Receptor-type tyrosine-protein phosphatase U |
| Background | Protein PTPRU |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PTPRU, also known as RPTPρ, is a receptor-like protein tyrosine phosphatase that regulates cell adhesion, migration, and differentiation. It contains extracellular immunoglobulin (Ig)-like and fibronectin type III domains, a transmembrane segment, and two intracellular phosphatase domains, with the first domain being enzymatically active. PTPRU is expressed in epithelial tissues, the nervous system, and during embryonic development. It interacts with cadherins and β-catenin, mediating cell adhesion and cytoskeletal organization. PTPRU regulates Wnt/β-catenin signaling, playing a role in cellular proliferation, differentiation, and tissue development. Its expression is developmentally regulated, and dysregulation has been linked to tumor progression in various cancers, including colorectal and breast cancer. PTPRU is also implicated in stem cell maintenance and differentiation, underscoring its importance in tissue homeostasis and development. Its ability to influence cellular adhesion and signaling makes it relevant for understanding cancer and developmental biology.
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