Human Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Protein
234€ (10 µg)
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name
Human Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650366
tested applications
WB, SDS-PAGE
Description
Human PTPRN2 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 24.0 kDa Observed MW (SDS-PAGE): 24 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys839-Gln1015 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92932 |
| Alias | IAR,ICAAR,PTPRP,IA-2beta,R-PTP-N2,Phogrin,Islet cell autoantigen-related protein,Receptor-type tyrosine-protein phosphatase N2 |
| Background | Protein PTPRN2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PTPRN2, also known as IA-2β or phogrin, is closely related to PTPRN and is predominantly expressed in neuroendocrine and neuronal tissues. Like PTPRN, PTPRN2 has a transmembrane region and an intracellular domain with a catalytically inactive phosphatase-like region. PTPRN2 plays a crucial role in insulin and neurotransmitter secretion by regulating secretory granule biogenesis, transport, and exocytosis. It is particularly involved in maintaining the structural integrity of granules and their exocytotic machinery. PTPRN2 is an autoantigen in type 1 diabetes, contributing to β-cell autoimmunity and destruction. It has also been implicated in neurological functions, including synaptic vesicle release and neurotransmitter regulation. Dysregulation of PTPRN2 has been associated with metabolic diseases and neuropsychiatric disorders, highlighting its significance in endocrine and neuronal cell function.
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