Human Receptor-Type Tyrosine-Protein Phosphatase Epsilon (PTPRE) Protein
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Description
Human PTPRE Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Receptor-Type Tyrosine-Protein Phosphatase Epsilon (PTPRE) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 22.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile346-Gln500 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23469 |
| Gene ID | 5791 |
| OMIM | 600926 |
| Alias | PTPE,HPTPE,R-PTP-EPSILON,Protein-tyrosine phosphatase epsilon,Receptor-type tyrosine-protein phosphatase epsilon |
| Background | Protein PTPRE |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PTPRE is a receptor-like protein tyrosine phosphatase that plays essential roles in cellular signaling, particularly in hematopoietic and neuronal systems. Structurally, PTPRE exists as two isoforms: a transmembrane receptor-type protein (RPTPε) and a non-receptor, intracellular cytoplasmic form (cyt-PTPε). Both isoforms share a common catalytic domain but differ in localization and functional regulation. PTPRE is involved in modulating signaling pathways such as those mediated by Src family kinases, integrins, and MAPK pathways. It influences osteoclast differentiation, insulin signaling, and energy metabolism. In the nervous system, PTPRE regulates ion channel activity and neuronal excitability. Dysregulation of PTPRE has been linked to metabolic disorders, including insulin resistance, and its overexpression can contribute to oncogenic signaling pathways in certain cancers.
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PTPRE antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.
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PTPRE Antibody is a Rabbit Polyclonal Antibody against PTPRE.
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Receptor-Type Tyrosine-Protein Phosphatase Epsilon (PTPRE) Antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq].
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