PTPRE antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | protein tyrosine phosphatase, receptor type, E (PTPRE) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 81 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P23469 |
| Gene ID | 5791 |
| Alias | PTPE,HPTPE,R-PTP-EPSILON,Protein-tyrosine phosphatase epsilon,Receptor-type tyrosine-protein phosphatase epsilon |
| Background | Antibody anti-PTPRE |
| Status | RUO |
| Note | Mol. Weight 81 kDa |
Descripción
PTPRE is a receptor-like protein tyrosine phosphatase that plays essential roles in cellular signaling, particularly in hematopoietic and neuronal systems. Structurally, PTPRE exists as two isoforms: a transmembrane receptor-type protein (RPTPε) and a non-receptor, intracellular cytoplasmic form (cyt-PTPε). Both isoforms share a common catalytic domain but differ in localization and functional regulation. PTPRE is involved in modulating signaling pathways such as those mediated by Src family kinases, integrins, and MAPK pathways. It influences osteoclast differentiation, insulin signaling, and energy metabolism. In the nervous system, PTPRE regulates ion channel activity and neuronal excitability. Dysregulation of PTPRE has been linked to metabolic disorders, including insulin resistance, and its overexpression can contribute to oncogenic signaling pathways in certain cancers.
Related Products
PTPRE antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.
Ver Producto
Receptor-Type Tyrosine-Protein Phosphatase Epsilon (PTPRE) Antibody
PTPRE Antibody is a Rabbit Polyclonal Antibody against PTPRE.
Ver Producto
Receptor-Type Tyrosine-Protein Phosphatase Epsilon (PTPRE) Antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq].
Ver Producto