Human Protein Kinase N2 (PKN2) Protein
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Description
Recombinant Protein Kinase N2 (PKN2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Kinase N2 (PKN2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 29.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu67-Ile312 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16513 |
| Background | Protein PKN2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor(SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
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Human Protein Kinase N2 (PKN2) Protein
Recombinant Protein Kinase N2 (PKN2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Ver ProductoHuman Protein Kinase N2 (PKN2) Protein
Recombinant Protein Kinase N2 (PKN2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Ver Producto