Human Protein Dok-7 (DOK7) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Protein Dok-7 (DOK7) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx386972
tested applications
ELISA
Description
Human Protein Dok-7 (DOK7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DOK7 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Protein Dok-7 (DOK7) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q18PE1 |
| Gene ID | 285489 |
| OMIM | 254300 |
| Alias | C4orf25,Protein Dok-7,Dok-7,CMS10,CMS1B,FADS3,Downstream of tyrosine kinase 7 |
| Background | Elisa kits for DOK7 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Docking protein 7 (DOK7) is an essential cytoplasmic adaptor protein that plays a pivotal role in neuromuscular junction (NMJ) development and function. It primarily acts by activating muscle-specific receptor tyrosine kinase (MuSK), a key receptor in the signaling cascade that organizes acetylcholine receptor (AChR) clustering, which is critical for synaptic transmission at the NMJ. DOK7 contains a pleckstrin homology (PH) domain and a phosphotyrosine-binding (PTB) domain that facilitate its interaction with phosphorylated receptors and downstream signaling molecules. Mutations in the DOK7 gene have been directly associated with congenital myasthenic syndrome (CMS), a disorder characterized by muscle weakness due to impaired synaptic function. These mutations often result in reduced MuSK activation and defective AChR clustering, underscoring the critical role of DOK7 in synaptic maintenance. Beyond its role in NMJ formation, emerging research suggests potential functions of DOK7 in other cellular signaling contexts, although these roles are less well understood. Its specificity for MuSK and its involvement in rare neuromuscular disorders highlight its significance in both basic biology and clinical research.
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