anti- DOK7 antibody
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Precio
Precio a consultar
Antibody anti-DOK7
proveedor
FineTestreference
FNab02506Tested Applications
ELISA, WB, IHCreactivity
humanstatus
RUOclonality
polyclonalDescripción
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor(AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
Background
DOK6 is an adaptor protein in the DOK family that interacts with RET and other receptor tyrosine kinases, promoting neuronal development and survival. It is highly expressed in the nervous system, particularly in sensory and motor neurons, where it regulates neurite outgrowth and axonal guidance through the activation of MAPK/ERK pathways. DOK6 interacts with signaling proteins via its PTB and PH domains to mediate downstream effects. It plays a role in neurotrophic signaling, and its dysregulation is linked to impaired neural differentiation and neurodevelopmental disorders. Studies highlight its importance in promoting axonal elongation and neuronal connectivity.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human
immunogen target
docking protein 7
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB, IHC
observerd MW
64 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
DOK6
alias
C4orf25,Protein Dok-7,Dok-7,CMS10,CMS1B,FADS3,Downstream of tyrosine kinase 7
uniprot id
note
This product is for research use only.
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
proveedor
FineTestreference
FNab02506Tested Applications
ELISA, WB, IHCreactivity
humanstatus
RUOclonality
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