Human Protein Argonaute 3 / EIF2C3 (AGO3) Protein
741€ (20 µg)
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935106861
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name
Human Protein Argonaute 3 / EIF2C3 (AGO3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693449
tested applications
SDS-PAGE
Description
Human AGO3 Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human EIF2C3 (Q9H9G7-1) (Met 1-Ala 860) was expressed, with a polyhistidine tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Argonaute 3 / EIF2C3 (AGO3) |
| Host | Insect |
| Origin | Human |
| Observed MW | Molecular Weight: 99.6 kDa Sequence Fragment: Met1-Ala860 Tag: N-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 88% (SDS-PAGE) |
| Size 1 | 20 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H9G7-1 |
| Gene ID | 192669 |
| OMIM | 607355 |
| Alias | EIF2C3 |
| Background | Protein AGO3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AGO3 is a member of the Argonaute protein family, playing a role in RNA-induced silencing complex (RISC)-mediated gene regulation. Similar to other Argonaute proteins, AGO3 contains a PAZ domain, which binds the 3' end of small RNAs, and a PIWI domain, but it lacks significant catalytic slicer activity. AGO3 is primarily involved in microRNA (miRNA)-mediated translational repression, aiding in the recruitment of other silencing machinery to target mRNAs. Although less characterized than AGO1 and AGO2, AGO3 is expressed ubiquitously and contributes to post-transcriptional gene silencing in processes such as developmental regulation, stress responses, and immune function. Dysregulation of AGO3 is associated with diseases such as cancer, where altered miRNA activity impacts oncogenic or tumor suppressor pathways, though its precise roles remain under investigation.
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