Human Protein Argonaute-3 (AGO3) Protein
702€ (20 µg)
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935106861
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name
Human Protein Argonaute-3 (AGO3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693449
tested applications
SDS-PAGE
Description
Protein Argonaute-3 (AGO3) protein is a recombinant Human protein expressed in Insect.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Argonaute-3 (AGO3) |
| Host | Insect |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Ala860 Tag: N-terminal His tag |
| Origin | Human |
| Observed MW | 99.6 kDa |
| Expression | Recombinant |
| Purity | > 88% (SDS-PAGE) |
| Size 1 | 20 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9H9G7-1 |
| Gene ID | 192669 |
| OMIM | 607355 |
| Alias | EIF2C3 |
| Background | Protein AGO3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
AGO3 is a member of the Argonaute protein family, playing a role in RNA-induced silencing complex (RISC)-mediated gene regulation. Similar to other Argonaute proteins, AGO3 contains a PAZ domain, which binds the 3' end of small RNAs, and a PIWI domain, but it lacks significant catalytic slicer activity. AGO3 is primarily involved in microRNA (miRNA)-mediated translational repression, aiding in the recruitment of other silencing machinery to target mRNAs. Although less characterized than AGO1 and AGO2, AGO3 is expressed ubiquitously and contributes to post-transcriptional gene silencing in processes such as developmental regulation, stress responses, and immune function. Dysregulation of AGO3 is associated with diseases such as cancer, where altered miRNA activity impacts oncogenic or tumor suppressor pathways, though its precise roles remain under investigation.
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