Protein Argonaute 3 / EIF2C3 (AGO3) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Protein Argonaute 3 / EIF2C3 (AGO3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037653
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the EIF2C3/AGO3 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Argonaute 3 / EIF2C3 (AGO3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H9G7 |
| Gene ID | 192669 |
| NCBI Accession | NP_079128 |
| OMIM | 607355 |
| Alias | EIF2C3 |
| Background | Antibody anti-AGO3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
AGO3 is a member of the Argonaute protein family, playing a role in RNA-induced silencing complex (RISC)-mediated gene regulation. Similar to other Argonaute proteins, AGO3 contains a PAZ domain, which binds the 3' end of small RNAs, and a PIWI domain, but it lacks significant catalytic slicer activity. AGO3 is primarily involved in microRNA (miRNA)-mediated translational repression, aiding in the recruitment of other silencing machinery to target mRNAs. Although less characterized than AGO1 and AGO2, AGO3 is expressed ubiquitously and contributes to post-transcriptional gene silencing in processes such as developmental regulation, stress responses, and immune function. Dysregulation of AGO3 is associated with diseases such as cancer, where altered miRNA activity impacts oncogenic or tumor suppressor pathways, though its precise roles remain under investigation.
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