Human Prostaglandin-H2 D-isomerase (PTGDS) ELISA Kit
546€ (96 tests)
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name
Human Prostaglandin-H2 D-isomerase (PTGDS) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx252947
tested applications
ELISA
Description
Human Prostaglandin-H2 D-isomerase (PTGDS) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Prostaglandin-H2 D-isomerase (PTGDS) concentrations in serum, plasma and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Prostaglandin-H2 D-isomerase (PTGDS) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 62.5 pg/ml - 4000 pg/ml |
| Sensitivity | 37.5 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P41222 |
| OMIM | 176803 |
| Background | Elisa kits for PTGDS |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Prostaglandin D2 Synthase (PTGDS) is an enzyme that catalyzes the isomerization of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2), a key lipid mediator involved in sleep regulation, allergic inflammation, vasodilation, and immune modulation PTGDS is highly expressed in the brain, heart, and male reproductive organs, where it participates in cerebrospinal fluid production, detoxification of free radicals, and maintenance of male fertility PGD2 plays a central role in allergic reactions, mediating bronchoconstriction in asthma and inflammation in rhinitis Dysregulation of PTGDS contributes to neurological disorders such as Alzheimer’s disease by facilitating tau phosphorylation, amyloid deposition, and oxidative stress PTGDS also serves as a biomarker for cardiovascular disease, brain injury, and central nervous system inflammation Its role in lipid signaling and antioxidant defense highlights its importance in both homeostasis and disease progression
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The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.
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