Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein

Este producto es parte de PCSK9 - Proprotein Convertase Subtilisin/Kexin Type 9
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein PCSK9

proveedor

Abbexa

reference

abx068698

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

PCSK9 is a serine protease that plays a central role in cholesterol metabolism by regulating the levels of low-density lipoprotein receptors (LDLR) on the cell surface. PCSK9 binds to LDL receptors, promoting their internalization and subsequent degradation in lysosomes, which reduces the uptake of LDL cholesterol (LDL-C) from the bloodstream. Elevated PCSK9 activity leads to hypercholesterolemia and increases the risk of cardiovascular disease due to excessive circulating LDL-C levels. In contrast, loss-of-function mutations in PCSK9 result in reduced LDL receptor degradation, leading to low plasma cholesterol levels and decreased cardiovascular risk. PCSK9 inhibitors, such as monoclonal antibodies (e.g., alirocumab and evolocumab), are highly effective therapies for hypercholesterolemia and cardiovascular disease, as they block PCSK9's activity, preserving LDL receptors on cell surfaces to enhance cholesterol clearance. Beyond lipid metabolism, PCSK9 has been implicated in inflammation, immune regulation, and other pathological processes, making it a versatile target for therapeutic intervention. Its crucial role in cholesterol homeostasis underscores its significance in cardiovascular health and disease management.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 25.4 kDa Observed MW (SDS-PAGE): 32 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln454-Cys679 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

PCSK9


dry ice

No


availability

Shipped within 5-7 working days.


alias

FH3,PC9,FHCL3,NARC1,LDLCQ1,NARC-1,HCHOLA3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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