Human Progesterone Receptor (PGR) Protein
221€ (10 µg)
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name
Human Progesterone Receptor (PGR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168691
tested applications
WB, SDS-PAGE
Description
Human PGR Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Progesterone Receptor (PGR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 20.4 kDa Observed MW: 24 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 50 µg/ml Sequence Fragment: Met1-Leu164 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06401 |
| Alias | PR,NR3C3,Nuclear receptor subfamily 3 group C member 3 |
| Background | Protein PGR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Progesterone receptor (PGR) is a nuclear receptor that mediates the effects of progesterone, a steroid hormone involved in regulating the female reproductive system and various physiological processes PGR plays a key role in processes such as the menstrual cycle, pregnancy, and embryogenesis It functions by binding to progesterone, which activates the receptor and induces changes in gene expression that control cell differentiation, apoptosis, and immune responses During pregnancy, PGR helps maintain uterine function and supports the development of the fetus In the menstrual cycle, it helps regulate the endometrial lining, preparing it for implantation of a fertilized egg In addition, PGR is involved in the regulation of breast tissue, where its activation is essential for mammary gland development and function Dysregulation of PGR signaling has been associated with various diseases, including hormone-driven cancers like breast cancer and endometrial cancer, where altered progesterone signaling contributes to tumor growth and progression PGR is also a target for therapies such as progestins used in birth control and hormone replacement therapies
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