Human Procollagen Type I N-Terminal Propeptide (PINP) Peptide (BSA)
1612€ (1 mg)
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935106861
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name
Human Procollagen Type I N-Terminal Propeptide (PINP) Peptide (BSA)
category
Proteins and Peptides
provider
Abbexa
reference
abx651181
tested applications
WB, SDS-PAGE
Description
Procollagen I N-Terminal Propeptide Protein (BSA) is a Human protein conjugated to BSA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Procollagen Type I N-Terminal Propeptide (PINP) |
| Origin | Human |
| Conjugation | BSA |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml |
| Expression | Synthetic |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | PINP,P1NP |
| Background | Protein PINP |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Procollagen Type I N-Terminal Propeptide (PINP) is a cleavage product released during the biosynthesis of type I collagen, which is the most abundant collagen type found in bones, skin, and connective tissues. It serves as a sensitive and specific biomarker for bone formation, reflecting the activity of osteoblasts and the overall rate of collagen synthesis. PINP is widely used in clinical and research settings to monitor bone metabolism, particularly in conditions such as osteoporosis, Paget's disease, and metabolic bone disorders. It is often measured to assess the effectiveness of anabolic or anti-resorptive treatments in improving bone health. PINP levels can also indicate increased collagen turnover in fibrotic diseases, including liver fibrosis and systemic sclerosis, where excessive extracellular matrix production occurs. PINP exists in two forms in circulation, the intact trimer and a smaller monomer, both of which are measurable through immunoassays. The protein's dynamic association with bone remodeling and extracellular matrix synthesis underscores its importance as a marker for tissue repair and fibrotic activity. Emerging research highlights its potential in oncology, where altered PINP levels are linked to metastatic bone disease and tumor-induced bone resorption.
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